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doi: 10.1007/s12602-023-10105-2
Nature Rev Genet
The high throughput screening campaign of the substance library provided several hit compounds one of those the drug-like aryl sulfonamide 40 that was subsequently optimized into 41 that is a metabolically stable and reversible IRAP inhibitor
It can also cause anxiety, a tingling sensation in your feet or hands, trouble sleeping, and constipation 2
