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Inflammatory cytokines, such as IL-17 and TNF-, are particularly important in the pathogenesis of HS (217)

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SARS-CoV-2 infection can induce death or damage to brain endothelial cells through SARS-CoV-2 protease, which cleaves the Nf-B essential modulator (NEMO), leading to BBB disruption and subsequent neuroinflammation [102]

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