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The result is an outcome that neither could produce independently

Breast carcinoma cells treated with a combination of doxorubicin, cyclophosphamide, and cisplatin exhibited increased DNA damage when cultured in low glucose conditions and mice harboring ER + breast tumors were more responsive to hormone therapy when fed a fasting mimicking diet (FMD) diet than when fed an ad libitum diet [170,171]

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Immune reprogramming is also systemic, as shown by reduced cytotoxic immunity and increased immunosuppression in pre-metastatic lungs and distant metastatic sites (179181)