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Numbness and tingling in hands, legs, and feet: These are signs of the crucial role Vitamin B12 plays in the proper functioning of the nervous system

NAD+ BENEFITS Selective NNMT inhibition substrate-site targeting with minimal off-target activity in preclinical models NAD+ salvage modulation studied for increasing intracellular NAD+ and SAM availability Adipose metabolism investigated for suppression of adipocyte lipogenesis in 3T3-L1 models Small molecule distinct mechanism from peptide-based metabolic compounds (GLP-1 agonists, etc.) Defined pharmacology IC of 1.2 M confirmed in published enzymatic assays WHAT RESEARCHERS LOOK AT NNMT enzyme inhibition kinetics and SAM/1-MNA substrate balance NAD+ and SAM level changes in adipocyte and hepatocyte cell models Lipogenesis suppression in 3T3-L1 differentiated adipocyte assays Polyamine flux enzyme upregulation (ODC, SSAT) and histone methylation In vivo efficacy in diet-induced obesity (DIO) murine models

Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans, Stier H., Vos E., Kenley D., Journal (Journal of Endocrinology and Metabolism, Volume 3, Issues 12, 2013, Pages 715)

Six clinical trials involving over 900 participants established this window through systematic dose-finding studies