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Graphical Abstract Keywords: Traumatic brain injury, Intranasal drug delivery, Mitochondrial function therapeutics, Blood brain barrier, Neuroprotection Highlights Noninvasive intranasal drugs administration bypass the BBB, and can be rapidly delivered from the nasal mucosa to the brain The intranasal delivery is an attractive route for mitochondria-targeted neuroprotective drugs administration Accurate screening of intranasal compounds based on physiochemical properties is crucial When optimizing the intranasal administration by nanocarriers, drugs protection from chemical and enzymatic degradation must be carefully applied The intranasal route offers means to pharmacologically counter TBI pathogenesis in austere combat settings