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Funding Statement This work was supported by the National Natural Science Foundation of China (grant number: 82074085), the Natural Science Foundation of Zhejiang Province (grant number: LQ22H280008) and the Postgraduate Scientific Research Fund of Zhejiang Chinese Medical University (grant number: 2022YKJ20)
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J (2009) The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications
Similar to most TRPs, TRPML is mainly up-regulated, but in some cases down-regulated, by phosphatidylinositol 3,5-bisphosphate [PI(3,5)P 2 ], found in lysosomes (Dayam et al., 2015

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