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doi: 10.1006/bbrc.2002.6531

Oliveira et al, 1998

Liraglutide was developed with a view to providing a human GLP-1 analogue with a suitable duration of action for daily use, but, inspired by its beneficial actions, the company now strived to develop a second generation version, optimised not only with respect to duration of action, but also with respect to effects on insulin secretion and food intake

The combined targeting of the BBB carriers of alanine and the transporter(s) of GSH could offer an alternative pathway to increase the brain delivery of branched copolypeptides with dopamine cargo