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Thus, while autophagy loss directly damages myelin, the resulting SASP-driven chemokine signalling is the primary driver of neuronal plasticity deficits and cognitive decline [71]

Similarly, other studies indicate that enhanced PS exposure may result in a pathological erythrocyte procoagulant phenotype, which may contribute to the development of a hypercoagulable state

Due to the distinct position of the conjugated N-terminal lipid between Cagri-CTR and Cagri-AMY 1 R, we also determined a structure of CTR-Gs in complex with an analogue of Cagri that lacked the lipid modification (CagriBB) to interrogate the contribution of the acylation to the conformation of Cagri-CTR complex

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