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It participates in the modulation of the activity and localization of numerous enzymes and receptors [147, 160, 161], takes part in the regulation of many physiological processes in the brain [147, 162], including synaptic plasticity [163, 164], axonal elongation, and neuronal survival [147, 165]

However, it will be important to maintain these good habits over time

In good agreement with the above-described processes, carnitine seems to be involved also in insulin sensitivity (Figure 1): it was observed that the muscle accumulation of fatty acyl-CoA derivatives or acyl metabolites inhibits both insulin signaling and glucose oxidation (Pietrocola et al., 2015

Ammonia diffuses freely across the bloodbrain barrier and is converted with alanine to glutamine by glutamine synthase