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AFS is the non-Addisons form of adrenal dysfunction, where the bodys stress response cannot keep up with lifes chronic stressors

doi: 10.1016/j.neuron.2023.05.003 88 RafiullahMSiddiquiK

Given the complex interactions between iron metabolism, oxidative stress, and neuroinflammation in ALS, future studies should integrate multi-omics profiling, longitudinal imaging, and targeted interventions to dissect how ferroptosis influences disease progression
