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In knockout animals lacking the receptor, the chronic weight reduction effect was abolished, confirming the pathway dependency

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14 As revealed by its crystal structure, unique structural features of NNMT include two alpha-helices at its N-terminus, a flexible loop, and a cap consisting of a beta-hairpin and two alpha-helices over the active site

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Age, weight, and other nutritional deficiencies also play a role in the right dosage

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