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So, we recommend using SL vitamin B12 rather than oral and IM, especially in patients who do not tolerate IM injection and patients who need prolonged vitamin B12 supplementation, such as patients with long-term metformin use and patients with pernicious anemia or with gastro-duodenal resection [51,52,53,54]

However, if the administered drug has a long half-life, blood levels may still be high when the patient awakes in the morning

For instance, a trial may find someone demonstrates faster reaction times or better memory recall after using a certain herb, but other trials on the same substance might find no significant effect