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As a protective mechanism, PM and its soluble components are primarily cleared by mucociliary mechanisms and renal excretion [45,46]

Challenges and future perspectives in the clinical translation of PLGA nanoparticles for PD The previously discussed preclinical studies have shown the benefits of loading drugs and natural compounds into PLGA nanoparticles to enhance therapeutic efficacy, minimize systemic toxicity, and overcome peripheral side effects associated with PD medications