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Also, inactivation of MEK1/2 by U0126 or knockdown of MEK1 or MEK2 increased AKT phosphorylation (Fig

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CHE not only significantly inhibits liver cancer cell proliferation through cell S-phase arrest, regulating the protein Bcl-2, increasing the proapoptotic protein Bax, and downregulating Bcl-xl but also disrupts the mitochondrial membrane potential
