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While direct evidence for NGFs efficacy in tinnitus patients remains to be established, its established role in neuronal survival, synaptic plasticity, and emotional regulation, combined with emerging bioinformatic evidence of its involvement in tinnitus-related synaptic processes, provides a compelling rationale for further investigating the hypothesis that targeting the NGF/TrkA pathway could simultaneously ameliorate auditory perceptive distortions and the debilitating emotional symptoms that often accompany chronic tinnitus (Gross et al., 2023

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the physician determines whether the combined approach is appropriate and how to structure each component Convenience preference: patients who strongly prefer not to self-inject and whose indication is compatible with oral delivery