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BIBW 2948 is the inhibitor of EGFR, and inhalation of BIBW 2948 (4-week treatment) reduced internalisation of EGFR but did not reduce mucin stores

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A relative GPX4 deficiency occurs due to glutathione (GSH) depletion, as cytosolic L-glutamine is preferentially used in the form of -ketoglutarate as fuel for the tricarboxylic acid (TCA) cycle at the expense of GSH production
