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116 Additional experimental evidence is needed to determine the optimal level of Se daily intake that can maximize health benefits, avoiding potential toxic effects

doi: 10.1038/s41467-021-24859-2 17 AlborziniaHFlrezAFKrethSBrcknerLMYildizUGartlgruberMet al

320 In GBM, TGF- critically contributes to immune evasion by suppressing the cytotoxic activity of CTLs and NK cells, thereby hindering the host immune response against tumor cells

These interactions form a highly competitive and dynamic metabolic network where nutrient availability, mitochondrial function, and metabolite-mediated signaling pathways collectively orchestrate immune surveillance and tumor progression