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Based on the evidence emerging from the recent trials showing that NAC can reduce exacerbations in patients with COPD, including those taking ICS, the 2020 Global Initiative for Chronic Obstructive Lung Disease (GOLD) report includes NAC, as well as other thiol-based drugs, as additional therapies to consider in the treatment of COPD [33]

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In humans, reduced cravings in substance use disorders have been seen in some early studies with the use of NAC [141]