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Low zinc levels heighten endothelial cell vulnerability to LPS-induced apoptosis, whereas higher intracellular zinc supports defenses against apoptosis, possibly via nitric oxide pathways [473]

Guan X, Li X, Yang X, Yan J, Shi P, Ba L, Cao Y, Wang P
Because the in-vitro (cell-culture) literature is large and biochemically interesting, while the human-trial literature is much smaller

In muscle, during fasting, or other stresses, the synthesis/degradation equilibrium is shifted toward degradation, resulting in loss of muscle mass