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Initially identified as nine fundamental biological drivers of aging (13), the list has been updated to include twelve hallmarks: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis (14)

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We often find that balancing hormones with Bioidentical Hormone Replacement Therapy is a great first step

References Lee, C., Zeng, J., Drew, B.G., Sallam, T., Martin-Montalvo, A., Wan, J., Kim, S.J., Mehta, H., Hevener, A.L., de Cabo, R., & Cohen, P