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Methods: For this review, we prioritized recent evidence, focusing on reviews and meta-analyses published between 2015 and 2025, sourced from PubMed and Google Scholar

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Another study involving 42 patients with chronic schizophrenia and a PANSS negative subscale score of 20 or greater showed that NAC-treated patients improved significantly more in PANSS total and negative subscale scores than the placebo group, though this difference was insignificant for positive and general psychopathology subscales (14)

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