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DSIP is not a substitute for healthy sleep hygiene addressing sleep environment, limiting caffeine/blue light, managing stress, and maintaining a stable schedule are still foundational

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They concluded: Vitamin B(12) treatment, which is simple, inexpensive, and low-risk, seems to be effective for patients suffering from RAS [recurrent aphthous stomatitis, or canker sores], regardless of the serum vitamin B(12) level. That research was conducted quite a while ago

A 2022 dose-response RCT (Yi et al., Geroscience) at 300/600/900 mg/day raised NAD+ dose-dependently with no safety issues at 60 days