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Selective autophagy is the main mode of autophagy-dependent ferroptosis, including (but not limited to) 1) degradation of intracellular ferritin (FTH1, FTL, and FTMT) and iron export protein (SLC40A1) via mitophagy and NCOA4 (Nuclear receptor coactivator 4)-mediated ferritinophagy [97,98,99,100]

Using HEI-OC1 cells and cochlear explants from mice, Li Y

Abbreviations CYP450: Cytochrome P450 UGT: UDP-glucuronosyltransferase NAT2: N-acetyltransferase 2 GST: Glutathione S-transferase SULT: Sulfotransferase PAHs: Polycyclic aromatic hydrocarbons HCAs: Heterocyclic amines mRNA: Messenger ribonucleic acid EROD: Ethoxyresorufin-O-deethylase IC 50 : Half maximal inhibitory concentration HLM: Human liver microsomes NSAIDs: Nonsteroidal anti-inflammatory drugs -9-tetrahydrocannabinol: Delta-9-tetrahydrocannabinol E-3174: Losartan Carboxylic Acid RLM: Rat liver microsomes CNS: Central nervous system -adrenoceptor blockers: Beta adrenoceptor blockers MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine PD: Probe drug NAPQ1: N-acetyl-p-benzoquinone imine DEN: Diethylnitrosamine CCl 4 : Carbon tetrachloride Ki: The inhibitory constant CsA: Ciclosporin A C max : Maximum concentration AUC: Area under the curve w/w: Weight in weight References Adiwidjaja J, Boddy AV, McLachlan AJ (2022) Physiologically based pharmacokinetic model predictions of natural product-drug interactions between goldenseal, berberine, imatinib and bosutinib

Modifier Rules for CPT 64483: RT, LT, Modifier 50, KX, and ASC Requirements Modifier RT and LT: Unilateral Procedure Reporting Rules Yes, cpt 64483 requires a modifier in most billing scenarios