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Modern drug discovery,HartC.1999 187

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Kato Y., Lambert C.A., Colige A.C., Mineur P., Noel A., Frankenne F., Foidart J.M., Baba M., Hata R.I., Miyazaki K., et al

Int J Pharm Bio Sci

Furthermore, there is evidence showing that NAC administration during pregnancy might counteract apoptosis and ROS-related genotoxicity by increasing glutathione levels and decreasing mitochondrial membrane depolarization within the cells (Amin et al., Our working hypothesis was that administration of the antioxidant NAC during prenatal life might increase glutathione levels, preventing the negative effects exerted by increased ROS resulting from maternal HFD administration on metabolic and behavioral endpoints in the offspring