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Description
As several of these residues are buried within the IMiD-binding site, we hypothesized that they might reflect differences in the binding mode of the dHTC1 spirosuccinimide compared to traditional glutarimide-based CRBN ligands
Adverse outcomes among patients on MTX include hepatotoxicity, hematotoxicity, testiculopathy, and lung problems (Shea et al., 2013)
Boca Raton, FL, USA: CRC Press (2025)
EBioMedicine 40 , 554563 (2019)
