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[PubMed: 19891681] 215

In addition, SIRT1 reduces oxidative stress and inflammation by inhibiting the nuclear factor kappa B (NF-B) signaling pathway, resulting in decreased production of inflammatory cytokines, including IL-1, interleukin-6 (IL-6), tumor necrosis factor (TNF-), and ROS (133135)

Senescent mitochondria not only produce more ROS due to inefficient electron transport but also exhibit impaired iron-sulfur cluster biogenesis, leading to improper iron handling and accumulation within the mitochondria, thus creating a potent internal source of oxidative stress (106,107)

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