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Cognitive dysfunction was assessed via novel object recognition testing, where ketamine 3 mg/kg impaired rats ability to distinguish new objects from familiar ones

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Alterations in the claudin levels can affect the intestinal barrier integrity in different ways depending on the type of claudin isoform 45

The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further