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Description
The analysis revealed that participants receiving cagrilintide plus semaglutide achieved a mean 20.4% reduction in body weight at 68 weeks, compared with a 3.0% reduction with placebo (estimated difference, -17.3 percentage points

Peptides as small as 35 amino acids can cross the blood-brain barrier if they contain lipophilic residues or transporter-binding motifs.

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doi:10.1007/s00213-017-4743-1 Unno K, Furushima D, Hamamoto S, et al