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Trimethylglycine (TMG) assists homocysteine to be metabolized into methionine, resulting in the production of DMG (dimethylglycine).* Further metabolism of TMG produces the enzyme methyltetrahydrofolate reductase (the active form of folic acid)

Chronic nitro-oxidative stress and hypernitrosylation inhibit the activity of those antioxidant systems, the tricarboxylic acid cycle, mitochondrial functions, and the metabolism of immune cells
