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This type of cochlear synaptopathy, referred to as hidden hearing loss because the deficits can hide behind a normal audiogram 11 , is posited to trigger neural hyperactivity that underlies tinnitus 19,20,21 , potentially offering a valuable drug target for the development of novel tinnitus treatments

Notably, the clinical phase III trial testing the therapeutic effect of Bardoxolone methyl, a potent Nrf2 activator, on chronic renal disease associated with type 2 diabetes was terminated because of an increased rate of cardiovascular events, including heart failure and deaths (Ouyang et al., 2014

The lesion has also been induced experimentally in lambs by exposure of pregnant ewes to hyperthermia during the last of pregnancy

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