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Mechanistically, intranasally administered agents may be absorbed through the olfactory epithelium or trigeminal nerve endings and transported to the brain via extracellular diffusion and intracellular axonal pathways, which may partially bypass BBB-related constraints (Raghav et al., 2023
At very high concentrations of hydroperoxide the selenium centre in GPx may be overoxidized to produce seleninic acid (ESeO 2 H) and selenonic acid (ESeO 3 H)
JAMA 327 , 885 (2022)
Oyagbemi AA, Omobowale TO, Ola-Davies OE, Asenuga ER, Ajibade TO, Adejumobi OA, et al
