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Representative traces of I SK1-3 at +80 mV in absence (Ctr) or presence of Sp-8-Br-cAMPS (cAMP, 10 M for 1 h)
The 12-month trial design enables us to assess senolytic-associated changes before and after treatment during the 3-month active treatment phase, track the reappearance of senescent cells after their removal during the 9-month post-treatment period, and evaluate disease trajectory differences over a one-year period (Figure 3)
10.1007/s11033-011-1262-8 186 ZongY.LiH.LiaoP.ChenL.PanY.ZhengY.et al (2024)
Stage 3: Method-of-Use Patent Expansion (Years 5-20 from NDA) Post-approval clinical research frequently generates new uses for approved drugs, either as single agents in new indications or as components of combination regimens
