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Liao Y, Hu R, Wang Z, Peng Q, Dong X, Zhang X, et al
Data on coronary artery disease have been contributed by CARDIoGRAMplusC4D investigators and have been downloaded from www.CARDIOGRAMPLUSC4D.ORG
Crucially, human hepatocytes exhibit 10-fold higher CPT1A sensitivity than rodent models, explaining dose-limiting hepatotoxicity (ALT elevation in 60% of non-stroke trials) [129]
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