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In most cases yes, but there are exceptions such as levodopa for Parkinsons disease and certain antibiotics

A prominent long-term issue is loss of lean body mass, comprising 39-45% of total weight reduction in trials like STEP-1, where semaglutide led to 6.92 kg lean mass loss alongside 15.3 kg overall weight drop, potentially impairing metabolic rate, physical function, and increasing sarcopenia risk in older adults without exercise mitigation

Thyroid Hormones : L-Carnitine could reduce the effectiveness of thyroid medications
