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The discrepancy between laboratory and dietary concentrations of hesperidin, the complexity of its bioavailability and metabolism and the need to control confounding factors in epidemiological studies are significant hurdles that must be addressed
Additionally, metagenomic analysis of ASD patients from the United States of America revealed that dysfunctional dopamine, GABA, and serotonin pathways are correlated with specific enzymes and oral microbes that may be responsible for these effects [314]

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