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in low- and middle-income countries, the 12-month prevalence of MDD reaches 5.9% (range: 3.8%10.4%) (5), and post-COVID-19, the incidence in adolescents and young adults (1825 years) increased by 40% compared with pre-pandemic levels (2)
Therefore, any baseline variability regarding these factors between trial participants may significantly undermine the value of a meta-analysis
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Similarly, NPY through activation of its Y1 receptor, was demonstrated to be critical for the development of allergic airway inflammation in mice [178]
