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The animal's left thorax was incised and the heart was exposed

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G., Forssmann, W

The reduction of metabolic flexibility, mitochondrial dysfunction, and accumulation of ectopic lipids, particularly in the liver and adipose tissue, promote a state of inflammaging, which is further aggravated by the diminished amplitude and robustness of endogenous rhythms in both the SCN and peripheral metabolic organs (Cardinali and Hardeland, 2017
