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High (injection) Bioavailability 863971-53-5 CAS # 5338394 PubChem ID Developed By 2011 Thomas Burris, PhD Saint Louis University (later University of Florida) Primary Benefits Powerfully activates ERR receptors to boost mitochondrial function, energy expenditure, and fat oxidationmimicking the metabolic effects of endurance exercise Induces aerobic exercise genetic programs without physical exertion, increasing oxidative muscle fibers and endurance capacity Reduces fat mass through enhanced metabolism rather than appetite suppression, supporting body composition improvements Amino Acid Sequence N/A (Small molecule, not a peptide) Dosing How much do I take

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As shown in Table 1 and Figure 6, in the pursuit of structurally diverse NNMT inhibitors, researchers have identified certain macrocyclic peptides that bind to NNMT, displaying potent inhibition with Half-maximal inhibitory concentration (IC 50 ) values as low as 229 nM (Van Haren et al., 2021)