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2 Gut microbiota dysbiosis as a key contributor to colitis pathogenesis 2.1 Intestinal microecological homeostasis: a fundamental determinant of mucosal immunity The gastrointestinal tract hosts a highly diverse and dynamic community of commensal microorganisms, including bacteria, viruses, fungi, and protozoa (58)

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If the vial was out for 8+ hours at room temperature (2025C), the conservative approach is to discard it and start a fresh vial

Low B12 levels have been associated with increased anxiety and depressive symptoms