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If these metabolic and mitochondrial pathways are indeed dysregulated as it presently appears, ME/CFS cells could be less able to respond to additional ATP demands (such as those imposed by exertion) since the responding pathways are already activated

[DOI] [PubMed] [Google Scholar] 200.Luci S, Hirche F, Eder K

Although pharmacological stimulation of the hypothalamicpituitarygonadal axis using agents such as human chorionic gonadotropin and selective oestrogen-receptor modulators may promote recovery, these interventions require specialised medical supervision

The armamentarium includes various medications that are tailored toward patient tolerability and considering underlying liver disease severity