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AST has been shown to influence core pathological mechanisms in neurodegenerative disease (e.g., AD), including the reduction of tau hyperphosphorylation and suppression of BACE1 activity, both of which are key contributors to neurofibrillary tangle formation and A production, respectively (Shi and Zhao, 2024)

Treatment with Na 2 S 2 led to the dose-dependent formation of PrSS and PrS(S) n S that was reversed with TCEP (Fig
