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Although ROS generation may not be an essential factor for aging (Lpez-Otn et al., 2013), they are more likely to exacerbate age-related diseases progression via oxidative damage and interaction with mitochondria (Dias et al., 2013)
[DOI] [PMC free article] [PubMed] [Google Scholar] Serdar M, Herz J, Kempe K, Lumpe K, Reinboth BS, Sizonenko Sv, et al

References Paoletti, A., Courtney-Martin, G., & Elango, R

thus the synthesis of GSH is under redox regulation
