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However, in individuals with insulin-resistant diseases, such as metabolic syndrome (MetS) or type 2 diabetes, this regulatory function is weakened, resulting in an excess of CM and apoB48-VLDL (6568)

New Trends Clin Neuropharmacol

Moreover, RAGE-AGE interactions reduce the activity of endothelial nitric oxide synthase, the enzyme that produces nitric oxide (Xu et al

They are comprised of a hydrophobic core filled with neutral lipids surrounded by a phospholipid monolayer coated with proteins
