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The reaction occurs by an SN2 mechanism, analogous to the Williamson synthesis of ethers (Section 18.2)
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261 Lysosomal dysfunction is considered a critical factor in the development of many diseases, 261 which may manifest as impaired acidification, abnormal expression of lysosomal enzymes, lysosomal membrane stability issues, transport defects, and defects in autophagosome/endosome-lysosome fusion
