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In fact, therapeutic doses of metformin (150 M) protect endothelial function by interacting with the orphan nuclear receptor Nur77/NR4A1 to reduce hyperglycaemic-induced ROS [113]

5 Increasing respiratory infections and hard-to-beat pathogens (eg, multidrug-resistant strains) have become a challenge in clinical practice, and conventional antibiotic therapies are increasingly ineffective due to limitations in tissue penetration, toxicity, or drug resistance
It reduces sperm quality through a variety of mechanisms, such as sex hormone deficiency, DNA damage, oxidative stress, apoptosis, spermatogenesis disturbance, and zinc finger protein deficiency

Since then, similar results related to the reduced availability of opioid receptors in the supraspinal regions in CCI to the sciatic nerve [135] and the spared nerve injury model [136] have been reported
