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doi: 10.1016/j.colsurfb.2018.01.010

Emerging evidence suggests that agents targeting cell death have considerable therapeutic potential in CD management, including apoptosis, necroptosis, pyroptosis, parthanatos, ferroptosis, autophagy-dependent cell death, cuproptosis, oxeiptosis, entotic cell death, netotic cell death, lysosome-dependent cell death, and alkaliptosis

Clinical investigations suggest that the cerebrospinal fluid (CSF) levels of HMGB1 in patients with subarachnoid hemorrhage (SAH) demonstrate a positive correlation with proinflammatory factors, such as IL6 and TNF, and that the degree of HMGB1 elevation is closely related to the severity of the disease [353]

HammoudAOWalkerJMGibsonMClowardTVHuntSCKolotkinRLet al