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Interestingly, in individuals with HVDAS, the ADNP-SIRT1-EB1/EB3 protein complex may regulate autophagy, which is dysregulated and negatively affects mitochondrial metabolism in autism [344]

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Additional interventions from uncontrolled studies or low-quality evidence reports include l-carnitine, branched-chain amino acids, zinc, and muscle relaxants (baclofen, methocarbamol, orphenadrine, and eperisone hydrochloride)
