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Bioavailability of oral carnitine dietary supplements is only in the order of 14 to 18% of dose and unabsorbed L-carnitine is mostly degraded by micoorganisims in the large intestine [3]

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[16] FishTMAO Paradox: Why Seafood Can Raise TMAO Yet Support Heart Health Seafood may acutely elevate circulating TMAO because it contains TMAO itself, but long-term fish consumption aligns with lower CVD risk in prospective evidence and is regularly recommended in heart-healthy dietary guidance