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Essentially, this system entails an upregulation of pro-inflammatory cytokines (like IL-6 and TNF-) and a downregulation of anti-inflammatory cytokines (like IL-10) [146]

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This D-retro-inverso configuration preserves the three-dimensional side-chain topology of the original FOXO4 sequence maintaining functional mimicry of the FOXO4 forkhead domains interaction surface with p53 while conferring exceptional proteolytic stability compared to the native L-amino acid sequence