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Description
That gap, between what is known, what is legal, and what people are already doing, is exactly what the FDA is being asked to close

Both nebulizer and dry inhalation powder were hypothesized to be successful alternatives for pulmonary distribution compared to IV injection form [47, 48]

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Abbreviations AGE: Advanced glycation end product AMD: Age-related macular degeneration AR: Aldose reductase ATM: Ataxia-telangiectasia mutated CMA: Chaperone-mediated autophagy FoxO3: Forkhead box O-3 HIF-1 : Hypoxia-inducible factor-1 HOPS: Homotypic fusion and protein sorting IOP: Intraocular pressure KEAP1: Kelch-like ECH-associated protein 1 LIR: LC3-interacting region mTORC1: Mechanistic target of rapamycin complex 1 NPDR: Nonproliferative diabetic retinopathy NQO1: NADPH quinone dehydrogenase 1 NRF2: Nuclear factor erythroid 2related factor 2 ONC: Optic nerve crush ONL: Outer nuclear layer PAS: Pre-autophagosomal structure PDR: Proliferative diabetic retinopathy PI3K: Phosphatidylinositol 3 kinase PI3P: Phosphatidylinositol 3-phosphate PINK1: PTEN-putative kinase 1 POAG: Primary open angle glaucoma POSs: Photoreceptor outer segments RGC: Retinal ganglion cell RPE: Retinal pigmented epithelial ROCK1: Rho-associated coiled-coil-containing protein kinase 1 ROS: Reactive oxygen species SOD: Superoxide dismutase TFEB: Transcription Factor EB TM: Trabecular meshwork UBA: Ubiquitin-associated UVRAG: UV radiation resistance-associated VEGFA: Vascular endothelial growth factor A References De Duve C, Wattiaux R
